Biomarkers of Periodontal Disease Progression
A Research Study for People with Periodontal (Gum) Disease
What is the "Biomarkers of Periodontal Disease Progression" study? It is a study to find better tests to determine which people with gum disease will have worsening of their disease so we can help make treatment more effective. It is being conducted by researchers at the University at Buffalo (UB).
Volunteers are needed for this study!
Who is eligible to join?
•Males and females, 25 years or older
•Must have at least 20 natural teeth with 12 in the back of the mouth
•Not be a user of tobacco products
•Not have diabetes
What will I be asked to do if I join this study?
•Come to the Periodontal Disease Research Center, at the UB South (Main St.) Campus, for study visits. There will be a screening visit and study visits every two (2) months for one (1) year, plus two follow-up visits
•Complete questionnaires and have body measurements take
•Agree to have blood, saliva, plaque and some fluid from between your teeth and gums taken at most study visits
•You will be in the study about 18 months
What will I get from joining the study?
•A complete Oral Health Examination at each study visit
•A complete set of x-rays taken (unless you have a recent set). You will get a copy to take to your usual dental provider
•Close monitoring of your periodontal status for one year
•Treatment of any periodontal sites that get worse during the year
•Complete periodontal treatment at the end of the year
•Compensation for time and travel
How do I join? If you would like to learn more about the “Biomarkers of Periodontal Disease Progression” study, please call us at:
Additional information can be found on the study website:
Will I have to pay for any of the examinations, x-rays, procedures or treatments I receive during the study? NO! You will not have to pay for the x-rays taken, or the exams, the monitoring or the treatments you receive.
Where will study visits take place? All study visits will take place at the Periodontal Disease Research Center. It is located in Foster Hall on the UB South (Main St) Campus. Free parking is provided. The Metro and bus station is very nearby.
How will participation in this study benefit me?,/b>
•You will be monitored closely for one year and then treated for your periodontal disease
•You will receive the periodontal care free of charge at the end of one year
•You will receive information on how to improve your oral health
What if I don’t know if I have periodontal (gum) disease? If you call us to ask about the study, we can ask you a few questions that might indicate if you are likely to have periodontal disease. If you are eligible for a screening visit, we will do an oral health examination and assess your periodontal status and tell you want it is.
How will my confidentiality be assured? All information obtained will be treated in strict confidence to the extent provided by law. You will be assigned a study identification number and your name will NOT be used in ANY reports resulting from this study.
How will the study affect my regular dental care? We will monitor your oral health status for the duration of the study. If you need periodontal treatment at a specific site, we will provide it. If you need other dental treatment, we will refer you to your own dentist or to a dental provider who can help you.
Who is funding this Study? The National Institute of Dental and Craniofacial Research is funding this study. It is being conducted at UB as well as at the Forsyth Institute in Boston, New York University, and the Universities of Florida and Michigan.
More Information on Periodontal (Gum) Disease: Periodontal (gum) disease can be bothersome, ugly and lead to additional health problems. Most people want to get rid of it or prevent it if they know about it. Gingivitis is the first stage of periodontal disease. Gums become red and swollen. They can bleed during brushing. If you brush regularly and well, and use dental floss too, you can usually reverse the process and prevent progression to periodontal disease.
Periodontal disease involves infection in the tissues that surround teeth and may range from mild to severe. That infection can lead to loss of bone which can result in loose or wobbly teeth that do not feel or look good. In the beginning, periodontal disease is not painful; later, there can be discomfort or pain, abscesses, loosening or loss of teeth, and a less attractive smile and appearance.
The goal of this study is to find better tests to determine which people with periodontal (gum) disease will have worsening of their disease. The development of a test for disease activity would provide information about the kind of treatment each person needs.
Volunteers are needed!