A cancer diagnosis can bring about a range of emotions. Some patients may feel angry or like they've lost control. Others may feel overwhelmed and alone. Many patients may also have concerns about their cancer treatment and the side effects it may bring.

One of the treatments for cancer is chemotherapy. The intention of chemotherapy is to kill cancer cells. However, at the same time, chemotherapy may cause damage to healthy cells as well. Sometimes when the body is exposed to the toxicity of chemotherapy the substance known as serotonin is released. Serotonin then sends a message to a part of your brain, triggering nausea and vomiting. Many patients report nausea and vomiting as one of the most unpleasant side effects of chemotherapy.

Prevention of nausea and vomiting associated with chemotherapy is an essential part of a chemotherapy treatment plan. If not properly prevented, approximately 70 to 80 percent of all patients receiving chemotherapy may experience chemotherapy-induced nausea and vomiting (CINV).

It is important for patients and their health care professionals to discuss prevention of CINV prior to starting chemotherapy. Patients should know that nausea and vomiting are more than just unpleasant side effects. Having nausea and vomiting following a cycle of chemotherapy can result in weight loss, dehydration and malnutrition. So it's important to have a plan that may help prevent it.

ALOXI (palonosetron HCL) injection is a medicine that can help prevent nausea and vomiting on the day of chemotherapy that is highly likely to cause nausea and vomiting and up to five days following chemotherapy that is moderately likely to cause nausea and vomiting. Be sure to discuss the potential side effects of your treatment with your health care professional and ask questions that will help you better manage the effects of chemotherapy, such as:

* What type of chemotherapy drugs will I be given, and how will I receive them?
* What are the chances that these drugs will cause me to have nausea and vomiting?
* If CINV may occur, when should I expect it, and how long will it last?
* What types of medication will I be given to help prevent the risk of CINV, and how will I take them?
* What other side effects could occur with this chemotherapy?
* Does my background or history increase my risk of experiencing CINV?
* Are there any other factors or treatments that could increase my risk of experiencing nausea and vomiting?
* What nondrug measures should I take to reduce my risk of CINV or to help if I experience CINV?
* What should I do if I feel that CINV is too severe or is lasting too long?
* What are the signs of dehydration?

Remember, each person's experience with chemotherapy is different. While you may have a friend or family member who experienced CINV, it doesn't mean that you will. Talk to your health care professional about your chemotherapy and whether you're at risk for CINV. You may be at risk if you:

* Are younger
* Are female
* Are prone to motion sickness or anxiety
* Are a light drinker (people who drink more alcohol are less likely to become nauseous)
* Had morning sickness when you were pregnant
* Previously experienced CINV


For more information ask your doctor or visit www.ALOXI.com" to view the full prescribing information.